Fig. 1. Pharmacokinetic model of cinacalcet. The absorbed drug has to overcome first pass metabolisms before it enters systemic circulation where it can be bound to protein, eliminated or distributed to the tissue compartments.
Fig. 1. Pharmacokinetic model of cinacalcet. The absorbed drug has to overcome first pass metabolisms before it enters systemic circulation where it can be bound to protein, eliminated or distributed to the tissue compartments.